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Литература 
1. Lok A.S., Heathcote 
E.J., Hoofnagle J.H. Management of Hepatitis B 2000, Summary of a Workshop. 
Gastroenterology 2001;120:1828-53. 
2. Gross P.A., Barrett T.L., Dellinger 
E.P., Krause P.J., Martone W.J., McGowan J.E., Sweet R.L., et al. Infectious 
Diseases Society of America quality standards for infectious diseases: purpose 
of quality standards for infectious diseases/ Clin Infect Dis 1994;18:421. 
3. Lee W. Hepatitis B virus infection. N Engl J Med 1997;337:1733-45. 
4. 
McQuillan G.M., Townsend T.R., Fields H.A., Carrol M., Leahy M., Polk B.F. 
Seroepidemiology of hepatitis B virus infection in the United States. Am J Med 
1989;87(suppl 3A):5S-10S. 
5. CDC. Hepatitis B virus: a comprehensive 
strategy for limiting transmission in the United States through universal 
childhood vaccination. Recommendations of the Immunization Practices Advisory 
Committee (ACIP). MMWR 1991;40:RR-13:1-25. 
6. Beasley R.P. Hepatitis B 
virus: the major etiology of hepatocellular carcinoma. Cancer 1988;61:1942-56. 
7. McMahon B.J. Hepatocellular carcinoma and viral hepatitis. In: Wilson 
R.A., ed. Viral Hepatitis. New York: Marcel Dekker 1997;315-330. 
8. Seeger 
C., Mason W.S. Hepatitis B virus biology. Microbiol Mol Biol Rev 2000;64:51-68. 
9. Ganem D., Schneider R.J. Hepadnaviridae and their replication. In: Knipe 
D.M., Howlev P.M., Chanock R.M., Monath T.P., Roizman B., Straus S.E., eds. 
Fields Virology. 4th ed. Philadelphia: Lippincott-Raven, 2001:2703-37. 
10. 
Scaglioni P.P., Melegari M., Wands J.R. Biologic properties of hepatitis B viral 
genomes with mutations in the precore promoter and precore open reading frame. 
Virology 1997;233:374-81. 
11. Buckwold V.E., Xu Z., Chen M., Yen T.S., Ou 
J.H. Effects of a naturally occurring mutation in the hepatitis B virus basal 
core promoter on precore gene expression and viral replication. J Virol 
1996;70:5845-51. 
12. Locarnini S., Birch C. Antiviral chemotherapy for 
chronic hepatitis B infection: lessons learned from treating HIV-infected 
patients. J Hepatol 1999;30:536-50. 
13. Maynard J.E. Hepatitis B: global 
importance and need for control. Vaccine 1990;8(Suppl):S18-S20. 
14. Mast 
E.E., Alter M.J., Margolis H.S. Strategies to prevent and control hepatitis B 
and C virus infections: a global perspective. Vaccine 1999;17:1730-33. 
15. 
Margolis H.S., Alter M.J., Hadler S.C. Hepatitis B: evolving epidemiology and 
implications for control. Semin Liver Dis 1991;11:84-92. 
16. CDC. 
Recommendations for protection against viral hepatitis. Recommendations of the 
Immunization Practices Advisory Committee (ACIP). MMWR 1985;34:313-35. 
17. 
CDC. Prevention of perinatal transmission of hepatitis B virus: prenatal 
screening of all pregnant women for hepatitis B surface antigen. Recommendations 
of the Immunization Practices Advisory Committee (ACIP). MMWR 1988;37:341-6. 
18. Scharschmidt B.F., Held M.J., Hollander H.H., Read A.E., Lavine J.E., 
Veereman G., McGuire R.F., et al. Hepatitis B in patients with HIV infection: 
relationship lo AIDS and patient survival. Ann Intern Med 1992;117:837-8. 
19. Rodriguez-Mendez M.L., Gonzalez-Quintela A., Aguilera A, Barrio E. 
Prevalence, patterns and course of past hepatitis B virus infection in 
intravenous drug users with HIV-1 infection. Am J Gastroenterol 2000;95:1316-22. 
20. Bond W.W., Favero M.S., Petersen N.J., Gravelle C.R., Eben J.W., Maynard 
J.E. Survival of hepatitis B virus after drying and storage for one week 
[letter]. Lancet 1981;1:550-1. 
21. Petersen N.J., Barrett D.H., Bond W.W., 
Berquist K.R., Favero M.S., Bender T.R., Maynard J.E. Hepatitis B surface 
antigen in saliva, impetiginous lesions, and the environment in two remote 
Alaskan villages. Applied Environ Microbiol 1976:32:572-4. 
22. Beasley R.P., 
Hwang L.Y., Lee G.C.Y., Lin C.C., Roan C.H., Huang F.Y., Chen C.L. Prevention of 
perinatally transmitted hepatitis B virus infections with hepatitis B immune 
globulin and hepatitis B vaccine. Lancet 1983;1:1099-1102. 
23. Beasley R.P., 
Hwang L.Y., Lin C.C., Leu M.L., Stevens C.E., Szmuness W., Chen K.P. Incidence 
of hepatitis B virus in preschool children in Taiwan. J Infect Dis 
1982;146:198-204. 
24. Corsaget P., Yvonnet B., Chotard J., Vincelot P., Sarr 
M., Diouf C., Chiron J.P., et al. Age- and sex-related study of hepatitis B 
virus chronic carrier state in infants from an endemic area (Senegal). J Med 
Virol 1987;22:1-5. 
25. McMahon B.J., Alward W.L.M., Hall D.B., Heyward W.L., 
Bender T.R., Francis D.P., Maynard J.E. Acute hepatitis B virus infection: 
Relation of age to the clinical expression of disease and subsequent development 
of the carrier state. J Infect Dis 1985;151:599-603. 
26. Tassopoulos N.C., 
Papaevangelou G.J., Sjogren M.H., Roumeliotou-Karayannis A., Gerin J.L., Purcell 
R.H. Natural history of acute hepatitis B surface antigen-positive hepatitis in 
Greek adults. Gastroenterology 1987;92:1844-50. 
27. Horvath J., Raffanti 
S.P. Clinical aspects of the interactions between human immunodeficiency virus 
and the hepatotropic viruses. Clin Infect Dis 1994;18:339-47. 
28. Bodsworth 
N., Donovan B., Nightingale B.N. The effect of concurrent human immunodeficiency 
virus infection on chronic hepatitis B: a study of 150 homosexual men. J Infect 
Dis 1989;160:577-82. 
29. Hoofnagle J.H., Dusheiko G.M., Seeff L.B., Jones 
E.A., Waggoner J.G., Bales Z.B. Seroconversion from hepatitis B e antigen to 
antibody in chronic type B hepatitis. Ann Intern Med 1981;94:744-8. 
30. 
Viola L.A., Harrison I.G., Coleman J.C., Paradinal F.J., Fluker J.L., Evans 
B.A., Murray-Lyon I.M. Natural history of liver disease in chronic hepatitis B 
surface antigen carriers: survey of 100 patients from Great Britain. Lancet 
1981;2:1156-9. 
31. Liaw Y.F., Chu C.M., Su I.J., Huang M.J., Lin D.Y., 
Chang-Chien C.S. Clinical and histological events preceding hepatitis B e 
antigen seroconversion in chronic type B hepatitis. Gastroenterology 
1983;84:216-9. 
32. Fattovich G., Rugge M., Brollo L., Pontisso P., Noventa 
F., Guido M., Alberti A., et al. Clinical, virologic and histologic outcome 
following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B. 
Hepatology 1986;6:167-72. 
33. Lok A.S.F., Lai C.L., Wu P.C., Leung E.K.Y., 
Lam T.S. Spontaneous hepatitis e antigen to antibody seroconversion and 
reversion in Chinese patients with chronic hepatitis B virus infection. 
Gastroenterology 1987;92:1839-43. 
34. Lok A.S., Lai C.L. A longitudinal 
follow-up of asymptomatic hepatitis B surface antigen-positive Chinese children. 
Hepatology 1988,8:1130-3. 
35. Chang M.H., Hsu H.Y., Hsu H.C., Ni Y.H., Chen 
J.S., Chen D.S. The significance of spontaneous hepatitis e antigen 
seroconversion in childhood: with special emphasis on the clearance of hepatitis 
e antigen before 3 years of age. Hepatology 1995;22:1387-92. 
36. Lee P.I., 
Chang M.H., Lee C.Y., Hsu H.Y., Chen J.S., Chen P.J., Chen D.S. Changes in serum 
hepatitis B DNA and aminotransferase levels during the course of chronic 
hepatitis B virus infection in children. Hepatology 1990;12:657-60. 
37. Lok 
A.S.K., Lai C.L. Acute exacerbations in Chinese patients with chronic hepatitis 
B (HBV) virus infection: Incidence, predisposing factors and etiology. J Hepatol 
1990;10:29-34. 
38. Dusheiko G.M., Brink B.A., Conradie J.D., Marimuthu T., 
Sher R. Regional prevalence of hepatitis B, Delta, and human immunodeficiency 
virus infection in Southern Africa: a large population survey. Am J Epidemiol 
1989;129:138-45. 
39. Bortolotti F., Cadrobbi P., Crivellaro C., Guido M., 
Rugge M., Noventa F., Calzia R., et al. Long-term outcome of chronic type B 
hepatitis in patients who acquire hepatitis B infection in childhood. 
Gastroenterology 1990;99:805-10, 
40. Moreno M.R., Otero M., Millan A., 
Castillo I., Cabrerizo M., Jimenez F.J., Oliva H., et al. Clinical and 
histological outcome after hepatitis B e antigen to antibody seroconversion in 
children with chronic hepatitis B. Hepatology 1999;29:572-5. 
41. Stroffolini 
T., Mele A., Tosti M.E., Gallo G., Balocchini E., Ragni P., Santonastasi F., et 
al. The impact of hepatitis B mass immunisation campaign on the incidence and 
risk factors of acute hepatitis B in Italy. J Hepatol 2000;33:980-5. 
42. de 
Franchis R., Meucci G., Vecchi M., Tatarella M., Colombo M., Del Ninno E., Rumi 
N.G., et al. The natural history of asymptomatic hepatitis B surface antigen 
carriers. Ann Intern Med 1993;118:191-4. 
43. McMahon B.J., Hoick P., Bulkow 
L., Snowball M.M. Serologic and clinical outcomes of 1536 Alaska Natives 
chronically infected with hepatitis B virus. Ann Int Med 2001;.135:759-68. 
44. Colin J.F., Cazals-Hatem D., Loriot M.A., Martinot-Peignoux M, Pham 
B.N., Auperin A., Degott C., et al. Influence of human immunodeficiency virus 
infection on chronic hepatitis B in homosexual men. Hepatology 1999;29:1306-10. 
45. Dragosics B., Ferenci P., Hitchman E., Denk H. Long-term follow-up study 
of symptomatic HBsAg-positive voluntary blood donors in Austria: a clinical and 
histologic evaluation of 242 cases. Hepatology 1987;7:302-6. 
46. Davis G.L., 
Hoofnagle J.H., Waggoner J.G. Spontaneous reactivation of chronic hepatitis B 
virus infection. Gastroenterology 1984;86:230-5. 
47. Liaw Y.F., Tai D.I., 
Chu C.M., Pao C.C., Chen T.J. Acute exacerbation in chronic type B hepatitis: 
comparison between HBeAg and antibody-positive patients. Hepatology 1987;7:20-3. 
48. Fattovich G., Brollo L., Alberti A., Pontisso P., Giustina G., Realdi G. 
Long-term follow-up of anti-HBe-positive chronic active hepatitis B. Hepatology 
1988;8:1651-4. 
49. Chan H.L.Y., Leung N.W.Y., Hussain M., Wong M.L., Lok 
A.S.F. Hepatitis B e antigen-negative chronic hepatitis B in Hong Kong. 
Hepatology 2000;31:763-8. 
50. Brunetto M.R., Oliveri F., Rocca G., Criscuolo 
D., Chiaberge E., Capalbo M., David E., et al. Natural course and response to 
interteron of chronic hepatitis B accompanied by antibody to hepatitis B e 
antigen. Hepatology 1989;10:198-202. 
51. Lindh M., Andersson A.S., Gusdal A. 
Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus - 
large-scale analysis using a new genotyping method. J Infect Dis 
1997;175:1285-93. 
52. Laras A., Koskinas J., Avgidis K., Hadziyannis S.J. 
Incidence and clinical significance of hepatitis B virus precore gene 
translation initiation mutations in e antigen-negative patients. J Viral 
Hepatitis 1998;5:241-8. 
53. Naoumov N.V., Schneider R., Grotzinger T., Jung 
M.C., Miska S., Pape G.R., Will H. Precore mutant hepatitis B virus infection 
and liver disease. Gastroenterology 1992:102:538-43. 
54. Rodriguez-Frias F., 
Buti M., Jardi R., Cotrina M., Viladomiu L., Esteban R., Guardia J. Hepatitis B 
virus infection: precore mutants and its relation to viral genotypes and core 
mutations. Hepatology 1995;22:1641-7. . 
55. Tu H., Xiong S.D., Trepo C., Wen 
Y.M. Frequency of hepatitis B virus e-minus mutants varies among patients from 
different areas of China. J Med Virol 1997;51:85-9. 
56. Shindo M., Hamada 
K., Koya S., Sokawa Y., Okuno T. The clinical significance of core promoter and 
precore mutations during the natural course and interferon therapy in patients 
with chronic hepatitis B Am J Gastroenterol 1999;94:237-45. 
57. Zarski J.P., 
Marcellin P., Cohard M., Lutz J.M., Bouche C., Rais A. Comparison of 
anti-HBe-positive and HBe-antigen-positive chronic hepatitis B in France. French 
Multicentre Group. J Hepatol 1994;20;636-40. 
58. Gray A.H., Fang J.W., Davis 
G.L., Mizokami M., Wu P.C., Williams R., Schuster S.M., et al. Variations of 
hepatitis B virus core gene sequence in Western patients with chronic hepatitis 
B virus infection. J Viral Hepatitis 1997;4:371-8. 
59. Grandjacques C., 
Pradat P., Stuyver L., Chevallier M., Chevallier P., Pichoud C., Maisonnas M., 
et al. Rapid detection of genotypes and mutations in the pre-core promoter and 
the pre-core region of hepatitis B virus genome: correlation with viral 
persistence and disease severity. J Hepatol 2000;33:430-9. 
60. Hadziyannis 
S. Hepatitis B e antigen negative chronic hepatitis B: from clinical recognition 
to pathogenesis and treatment. Viral Hepatitis Rev 1995;1:7-36. 
61. Di Marco 
V., Camma C., Vaccaro A., Giunta M., Martorana G., Fuschi P., Almasio P., et al. 
The long-term course of chronic hepatitis B. Hepatology 1999;30:257-64. 
62. 
Brunetto M.R, Giarin M.M., Oliveri F., Chiaberge E., Baldi M., Alfarano A., 
Serra A., et al. Wild-type and e antigen-minus hepatitis B viruses and course of 
chronic hepatitis. Proc Natl Acad Sci U S A 1991;88:4186-90. 
63. Chu C.M., 
Yeh C.T., Chiu C.T., Sheen I.S., Liaw Y.F. Precore mutant of hepatitis B virus 
prevails in acute and chronic infections in an area in which hepatitis B is 
endemic. J Clin Microbiol 1996;34:1815-8. 
64. Kramvis A., Kew M.C., Bukofzer 
S. Hepatitis B virus precore mutants in serum and liver of Southern African 
blacks with hepatocellular carcinoma. J Hepatol 1998;28:132-41. 
65. Lok 
A.S., Akarca U., Greene S. Mutations in the pre-core region of hepatitis B virus 
serve to enhance the stability of the secondary structure of the pre-genome 
encapsidation signal. Proc Natl Acad Sci USA 1994;91:4077-81. 
66. Carman 
W.F., Jacyna M.R., Hadziyannis S., Karayiannis P., McGarvey M.J., Makris A., 
Thomas H.C. Mutation preventing formation of hepatitis B e antigen in patients 
with chronic hepatitis B infection. Lancet 1989;2:588-91. 
67. Okamoto H., 
Tsuda F., Akahane Y., Sugai Y., Yoshiba M., Moriyama K., Tanaka T., et al. 
Hepatitis B virus with mutations in the core promoter for an e antigen-negative 
phenotype in carriers with antibody to e antigen. J Virol 1994;68:8102-10. 
68. Magnius L.O., Norder H. Subtypes, genotypes and molecular epidemiology 
of the hepatitis B virus as reflected by sequence variability of the S-gene. 
Intervirology 1995;38:24-34. 
69. Adachi J., Kaneko S., Matsushita E., 
Inagaki Y., Unoura M., Kobayashi K. Clearance of HBsAg in seven patients with 
chronic hepatitis. Hepatology 1992;16:1334-7. 
70. LiawY.F., Sheen I.S., Chen 
T.J., Chu C.M., Pao C.C. Incidence, determinants and significance of delayed 
clearance of serum HBsAg in chronic hepatitis B virus infection: a prospective 
study. Hepatology 1991;13:627-31. 
71. Gandhi M.J., Yang G.G., McMahon B., 
Vyas G. Hepatitis B virions isolated with antibodies to the pre-S1 domain reveal 
occult viremia in surface antigen negative/antibody-positive carriers by 
polymerase chain reaction. Transfusion 2000:40:910-6. 
72. Yu M.W., Hsu F.C., 
Sheen I.S., Chu C.M., Lin D.Y., Chen C.J., Liaw Y.F. Prospective study of 
hepatocellular carcinoma and liver cirrhosis in asymptomatic chronic hepatitis B 
virus carriers. Am J Epidemiol 1997;145:1039-47.